July 23, 2026 · Obstetrics and gynecology · DOI: 10.1097/AOG.0000000000006381

Influence of Cardiometabolic Status on Cardiovascular Effects of Oral Menopausal Hormone Therapy

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The authors aimed to evaluate how cardiometabolic status influences the cardiovascular risks associated with menopausal hormone therapy (MHT) in postmenopausal women. Their analysis of two large randomized controlled trials revealed that while MHT did not increase coronary heart disease (CHD) risk in women with favorable lipid profiles, those with elevated LDL cholesterol levels faced significantly higher risks. The findings suggest that assessing lipid profiles could be crucial in determining the suitability of MHT for individual patients.

Jacques E Rossouw, Aaron K Aragaki, JoAnn E Manson, Emily D Szmuilowicz, Laura B Harrington, Matthew Allison, Bernhard Haring, Matthew Nudy, John W Davis, Andrea Z LaCroix

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