July 15, 2026 · Climacteric : the journal of the International Menopause Society · DOI: 10.1080/13697137.2026.2689718

Menopause and epigenetic changes: a review

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This review examines the epigenetic changes associated with menopause, specifically how hormonal fluctuations impact mechanisms like DNA methylation and microRNA expression, which can influence aging and increase the risk of chronic diseases such as osteoporosis and cardiovascular disease. The authors aim to highlight the potential of these epigenetic alterations as biomarkers for early disease detection and as targets for personalized therapies, while also considering the role of environmental factors and lifestyle modifications in mitigating health risks during menopause.

Belma Gözde Özdemir, Çetin Çelik

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