Climacteric
Audio Summaries

Photobiomodulation and pelvic floor training for genitourinary syndrome: RCT results

Aug 7, 2026

This study aimed to assess the effects of photobiomodulation (PBM) alone and in combination with pelvic floor muscle training (PFMT) on pelvic floor function, sexual and urinary health, and quality of life in menopausal women with genitourinary syndrome. The results indicated that while there were no significant differences in pelvic floor muscle pressure, the combination of PFMT and active PBM led to significant improvements in sexual function and clinically meaningful enhancements in urinary function compared to the sham treatment.

Menarche, menopause, reproductive life span and menopause-specific quality of life: a cohort study

Aug 7, 2026

This study aimed to explore how the age of menarche, age at menopause, and reproductive life span relate to menopausal symptoms in midlife Chinese women. The findings revealed that earlier menopause and a shorter reproductive life span were linked to increased discomfort in the sexual domain of the Menopause-Specific Quality of Life (MENQOL) questionnaire, while associations with vasomotor symptoms emerged in postmenopausal analyses. No significant relationships were found for psychosocial or physical domains.

The enigma of associations between reproductive health and development of osteoarthritis in midlife: a life-course approach

Aug 5, 2026

This narrative review investigates the complex associations between reproductive health factors and the development of osteoarthritis (OA) in midlife, particularly in relation to menopause and estrogen levels. The authors analyze 15 studies over 26 years, highlighting the variability in findings regarding factors such as parity, contraceptive use, and breastfeeding, while emphasizing the need for further research on the role of progesterone in OA etiology. The review underscores the importance of considering confounding variables in future studies to better understand these relationships.

Mortality trends in US patients with gynecologic cancer and cardiovascular disease

Jul 29, 2026

This study investigates mortality trends among US women aged 25 and older who have both gynecologic cancer and cardiovascular disease, utilizing national death certificate data from 1999 to 2023. The authors found a 49% increase in deaths over the study period, with stable overall age-adjusted mortality rates but significant disparities based on age, race, geography, and urbanization. The results underscore the need for integrated care approaches to address these inequities in health outcomes.

Identification and importance analysis of osteoporosis risk factors in perimenopausal women based on the Transformer-LSTM hybrid model and SMOTE

Jul 29, 2026

This study aims to identify key risk factors for osteoporosis in perimenopausal women using a novel analytical framework that combines a Transformer-LSTM hybrid model with the SMOTE algorithm for data balancing. The findings highlight total type 1 collagen N-terminal propeptide (TP1NP) as the most critical physiological indicator, along with other significant factors such as educational level and body weight. The proposed model demonstrates improved classification performance, suggesting its potential for enhancing early diagnosis and personalized interventions for osteoporosis in this population.

Comparing aerobic and resistance training in estrogen deficiency: bone and muscle adaptations

Jul 23, 2026

This study aimed to compare the effects of aerobic and resistance training on bone and muscle adaptations in ovariectomized mice, a model for estrogen deficiency. The results showed that both exercise modalities improved bone metabolism, but resistance training had more pronounced effects, including increased osteocyte density and muscle fiber size, suggesting it may be a more effective strategy for mitigating bone deterioration associated with menopause.

Humic acid from biomass attenuates ovariectomy-induced metabolic and bone changes in mice

Jul 15, 2026

The authors aimed to evaluate the effects of biomass-derived humic acid (HA) on metabolic dysfunction and bone loss induced by estrogen deficiency in ovariectomized mice. Their findings indicate that HA administration significantly attenuates weight gain, dyslipidemia, and bone mineral loss associated with ovariectomy, suggesting its potential as an adjunct therapy for managing metabolic and skeletal issues related to estrogen deficiency.

Assessing the burden of menopausal symptoms and their influence on women's quality of life

Jul 15, 2026

This study aimed to assess the prevalence and factors influencing impaired quality of life among Bangladeshi women experiencing menopause. The findings revealed that 27.5% of participants reported impaired quality of life, with vasomotor symptoms, particularly hot flushes, being the strongest predictor, especially during early postmenopause. The authors emphasize the need for routine symptom assessment and culturally tailored care to address the challenges faced by women during this transitional period.

Menopause and epigenetic changes: a review

Jul 15, 2026

This review examines the epigenetic changes associated with menopause, specifically how hormonal fluctuations impact mechanisms like DNA methylation and microRNA expression, which can influence aging and increase the risk of chronic diseases such as osteoporosis and cardiovascular disease. The authors aim to highlight the potential of these epigenetic alterations as biomarkers for early disease detection and as targets for personalized therapies, while also considering the role of environmental factors and lifestyle modifications in mitigating health risks during menopause.

A biopsychosocial framework for scalable menopause care: integrating cognitive behavioral therapy and digital therapeutics

Jul 13, 2026

The authors aim to address the challenges in providing effective menopause care by proposing a biopsychosocial framework that integrates cognitive behavioral therapy (CBT) and digital therapeutics. They highlight the need for scalable, evidence-based interventions to improve access and address the multifaceted nature of menopause symptoms, advocating for the use of digital health solutions to enhance care delivery. This approach seeks to create a more equitable and personalized healthcare experience for women experiencing menopause.