l-Proline as a safer strategy to preserve ovarian function for patients facing gonadotoxic therapies

The authors aimed to evaluate l-proline as a safer alternative to dimethyl sulfoxide (DMSO) for preserving ovarian function in patients undergoing gonadotoxic therapies. Their study found that l-proline effectively maintained key follicular metrics, such as estradiol secretion and viability, comparable to DMSO, while also demonstrating a better biosafety profile. These results suggest that l-proline could enhance the safety of clinical fertility preservation strategies.