March 20, 2026 · Climacteric : the journal of the International Menopause Society · DOI: 10.1080/13697137.2025.2610485

A narrative review of energy expenditure and substrate oxidation during menopause

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This narrative review aims to explore the changes in energy expenditure and substrate oxidation during menopause, particularly focusing on how the menopausal transition affects various components of energy expenditure and metabolism. The authors highlight a decline in resting and sleeping energy expenditure, fat oxidation, and physical activity energy expenditure, attributing these changes to hormonal adaptations associated with decreasing estrogen and increasing follicle stimulating hormone (FSH) levels. Overall, the review seeks to fill the knowledge gap regarding the energetic adaptations during this critical life stage.

Camille Marcantei, Lore Metz, Emma O'Donnell, Laurie Isacco

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