July 15, 2026 · Climacteric : the journal of the International Menopause Society · DOI: 10.1080/13697137.2026.2688264

Humic acid from biomass attenuates ovariectomy-induced metabolic and bone changes in mice

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The authors aimed to evaluate the effects of biomass-derived humic acid (HA) on metabolic dysfunction and bone loss induced by estrogen deficiency in ovariectomized mice. Their findings indicate that HA administration significantly attenuates weight gain, dyslipidemia, and bone mineral loss associated with ovariectomy, suggesting its potential as an adjunct therapy for managing metabolic and skeletal issues related to estrogen deficiency.

Eric Francelino Andrade, Hellen Paulo Silva, Thays Cristina Dos Santos, Karen Rodrigues Lima, Maíra Gabrielle de Abreu Ribeiro, Pedro Gustavo Machado, Maria Luiza Nonato Salvador, Jaqueline do Carmo Lima, Débora Ribeiro Orlando, Leonara Teixeira Alves, Elizabethe Adriana Esteves, Marco Fabrício Dias-Peixoto, Alan Rodrigues Teixeira Machado, Leonardo Barros Dobbss, Luciano José Pereira

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