Prenatal Acetaminophen (Paracetamol) Use and the Risk of Autism and/or Attention-Deficit/Hyperactivity Disorder Among Sibling-Matched Cohorts
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The authors aimed to investigate the association between prenatal exposure to paracetamol (acetaminophen) and the risk of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) in offspring, utilizing a sibling-matched cohort design to control for familial confounding. Their findings indicated no significant association between prenatal paracetamol use and the development of ASD or ADHD, suggesting that previously observed positive correlations in conventional studies may be due to residual familial factors. This research provides reassurance regarding the safety of paracetamol use during pregnancy.
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