Intravascular Hemolysis and Pulsed-Field Ablation: State of the Art Review
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This review investigates the incidence and clinical implications of intravascular hemolysis (IH) as a complication of pulsed-field ablation (PFA), synthesizing data from studies conducted between 2020 and 2025. The authors assess the interpretability of these studies based on biomarker kinetics and energy delivery determinants, concluding that while IH is common, it is rarely clinically significant, particularly in patients without renal dysfunction. They recommend tailored ablation strategies and selective biomarker screening for high-risk patients to mitigate complications.
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