Mice lacking NF-ĸB1 undergo premature ovarian aging
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The authors investigate the role of NF-ĸB1 in ovarian aging, specifically whether its absence contributes to premature ovarian aging in mice. They find that mice lacking NF-ĸB1 exhibit accelerated depletion of the ovarian reserve and increased levels of chronic inflammation, suggesting that NF-ĸB1 plays a critical role in regulating follicle loss and fertility as females age. Their findings indicate that low-grade inflammation linked to the loss of NF-ĸB1 may drive early onset of ovarian dysfunction and menopause.
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