June 11, 2026 · Reproductive biology and endocrinology : RB&E · DOI: 10.1186/s12958-026-01575-4

How endometrial thickness affects pregnancy and perinatal outcomes: a retrospective study of 16,566 frozen-thawed single blastocyst transfer cycles

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This study investigates the impact of endometrial thickness (EMT) on pregnancy and perinatal outcomes in 16,566 frozen-thawed single blastocyst transfer cycles. The authors found that an EMT of ≤ 7 mm is linked to lower live birth rates and higher risks of miscarriage and preterm birth, while an EMT > 10 mm is associated with improved live birth odds without increasing adverse outcomes. The findings suggest that EMT alone should not dictate the cancellation of embryo transfers, and that maternal age and BMI may influence these outcomes, indicating the need for personalized treatment approaches.

Luyang Zha, Lin Yu, Chenlu Zhang, Huahua Jiang, Dijia Bai, Zhaojin Du, Yaxin Guo

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