Association of Fetal Cerebrovascular Resistance and Neurodevelopment in Congenital Heart Disease: A Physiology-Based Analysis
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The authors aimed to determine whether fetal cerebrovascular resistance, as measured by the middle cerebral artery pulsatility index (MCA PI) and cerebroplacental ratio (CPR), can predict neurodevelopmental outcomes at 2 years of age in children with congenital heart disease (CHD). The study found that while there were no overall associations between cerebrovascular measures and neurodevelopment in CHD, lower MCA PI and CPR were linked to better cognitive and language scores specifically in cases with systemic outflow tract obstruction and single ventricle physiology. This suggests that the relationship between cerebrovascular resistance and neurodevelopment is influenced by the specific type of CHD.
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