Determining Ethnic Disparities Inherent to Tier 3 Vs. Tier 4 Carrier Screening
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The authors aimed to evaluate ethnic disparities in carrier status ascertainment between Tier 3 and Tier 4 carrier screening panels and to assess the effectiveness of Tier 4-only screening in a diverse population. Their findings indicate that Tier 4 panels significantly improve carrier detection across various ethnic groups, with a high prevalence of Tier 4-only variants and lower numbers needed to screen compared to Tier 3 panels. This supports the recommendation for universal Tier 4 carrier screening to better serve underrepresented populations.
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