Is There Potential Clinical Utility in Reporting Variants of Uncertain Significance From Prenatal Sequencing?
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The authors investigate the clinical utility of reporting variants of uncertain significance (VUS) identified through prenatal sequencing, particularly in the context of multidisciplinary team discussions. They found that VUS were reported in 41 out of 881 cases, with follow-up data indicating that over 50% of VUS were resolved through additional information, suggesting that reporting these variants can provide valuable insights for clinical decision-making despite initial uncertainties for parents.
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