Indications and Efficacy of Progestogen-Monotherapy as Menopause Hormone Therapy: A Narrative Review

This narrative review investigates the indications and efficacy of progestogen monotherapy as an alternative to estrogen-containing menopausal hormone therapy (MHT) for women with contraindications to estrogen. The authors find that progestogen monotherapy effectively alleviates vasomotor symptoms and offers various benefits, including improved sleep quality and potential bone protection, although its long-term safety, particularly regarding breast cancer risk, remains uncertain. They emphasize the need for larger, high-quality studies to establish clearer guidelines for its use in clinical practice.