July 6, 2026 · BJOG : an international journal of obstetrics and gynaecology · DOI: 10.1111/1471-0528.70300

Labour Dynamics After Induction in Nulliparous IVF/ICSI and Spontaneous Pregnancies: A Matched Cohort Study

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The authors aimed to compare labor dynamics between nulliparous women with IVF/ICSI and those with spontaneous pregnancies, particularly examining the impact of epidural analgesia on vaginal birth outcomes. The study found that spontaneous conceptions had higher rates of vaginal delivery and shorter active labor compared to IVF/ICSI pregnancies, which were associated with reduced labor progression and a higher likelihood of cesarean delivery. Additionally, while epidural analgesia delayed labor timing, it did not affect the overall likelihood of vaginal delivery in spontaneous pregnancies, and no significant impact was observed in IVF/ICSI cases.

Anna Seidenari, Sara Doroldi, Maria Cecilia Rinaldi, Sofia Calisti, Chiara Sollevanti, Cristina Scollo, Giuseppe Scibilia, Danila Morano, Antonio Farina

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