June 5, 2026 · Reproductive biology and endocrinology : RB&E · DOI: 10.1186/s12958-026-01573-6

Optimal selection of ovarian stimulation protocol for infertile women with diminished ovarian reserve based on Bologna and POSEIDON criteria: a network meta-analysis

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The authors aimed to determine the optimal ovarian stimulation protocol for infertile women with diminished ovarian reserve (DOR) by comparing five commonly used protocols through a network meta-analysis, stratified by Bologna and POSEIDON criteria. The findings suggest that the double ovarian stimulation (DOS) protocol is most effective for Bologna criteria patients, while the GnRH agonist protocol yields the best outcomes for POSEIDON group 3 patients. The study emphasizes the need for individualized stimulation strategies to improve clinical outcomes for DOR patients.

Ting Zhu, Jie Zhang, Xiaoyu Zhang, Yutian Zhou, Chaoyi Wang, Yi Qian, Jinyong Liu, Dan Zhou, Juan Jiang, Yan Meng

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