Diagnosis-dependent metabolic reprogramming of follicular fluid
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The authors aimed to characterize and compare the amino acid profiles in follicular fluid (FF) from patients undergoing in vitro fertilization (IVF) with various infertility-related disorders, including insulin resistance (IR), endometriosis (EM), and thyroid dysfunction (TD). Their findings indicate that while the overall amino acid composition of FF is largely conserved, specific metabolic alterations associated with each disorder can be detected, independent of body mass index (BMI). This study highlights the potential of using metabolic patterns in FF to enhance the understanding of reproductive dysfunction.
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