Malignant transformation risk and management dilemmas of atypical lobular endocervical glandular hyperplasia: A retrospective cohort study comparing Peutz-Jeghers syndrome versus sporadic cases
Listen to this summary
The authors aimed to compare the clinical characteristics and malignant potential of atypical lobular endocervical glandular hyperplasia (ALEGH) in patients with Peutz-Jeghers syndrome (PJS) versus sporadic cases to inform management strategies. The study found that PJS-associated ALEGH presented at a younger age and had a higher risk of malignant progression to gastric-type endocervical adenocarcinoma, particularly in cases that deferred hysterectomy. The findings suggest that prompt hysterectomy is recommended for PJS patients, while those opting for fertility preservation require close monitoring, although an optimal surveillance protocol is yet to be defined.
This is one of 33,000+ journals available on OSLR. Try it free for 14 days.
Free 14-day trial. 33,000+ journals. Cancel anytime.
More from Gynecologic oncology
View all →Jun 25, 2026 · Gynecologic oncology
FIGO 2023 staging may result in overtreatment of early-stage endometrial cancer
Jun 25, 2026 · Gynecologic oncology
Technical evaluation of commercially available homologous recombination deficiency assays using MyChoice CDx as reference in ovarian cancer
Jun 23, 2026 · Gynecologic oncology
Diagnostic value of FAM19A4/SOX1/PAX1 methylation in non-16/18 high-risk HPV cervical lesions
Jun 19, 2026 · Gynecologic oncology
Occult invasive and preneoplastic lesions at risk-reducing salpingo-oophorectomy in BRCA1/2 carriers: A multicenter retrospective cohort study
Jun 15, 2026 · Gynecologic oncology
Could chemotherapy response score act as a surrogate marker of response to PARP inhibitor maintenance treatment in patients with advanced ovarian cancer?
Jun 15, 2026 · Gynecologic oncology
Prehabilitation during neoadjuvant chemotherapy in advanced ovarian cancer is associated with improved surgical candidacy and chemotherapy outcomes
More in Obstetrics & Gynecology
View all →Jun 26, 2026 · Reproductive biology and endocrinology : RB&E
Mice lacking NF-ĸB1 undergo premature ovarian aging
Jun 25, 2026 · Prenatal diagnosis
Association of Fetal Cerebrovascular Resistance and Neurodevelopment in Congenital Heart Disease: A Physiology-Based Analysis
Jun 25, 2026 · International urogynecology journal
Predictors of Perceived Sports Performance in Female Athletes: The Role of Pelvic Floor Dysfunction and Sleep Quality
Jun 25, 2026 · Menopause (New York, N.Y.)
Processed foods in the context of a vegan diet, and changes in body weight and severe hot flashes in postmenopausal women: a secondary analysis of a randomized clinical trial
Jun 25, 2026 · BMC women's health
Mediterranean diet adherence and metabolic parameters in women with polycystic ovary syndrome: a retrospective cross-sectional study
Jun 25, 2026 · Prenatal diagnosis
Prenatal Genetic Testing for Beckwith-Wiedemann Syndrome: Considerations, Challenges and Observations (A Real-World Study)
"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."
Dr. Jennifer Thompson
Portland, OR
Stay current without falling behind
33,000+ journals. 3-minute audio summaries. Free for 14 days.
