Diagnostic value of FAM19A4/SOX1/PAX1 methylation in non-16/18 high-risk HPV cervical lesions
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The authors aimed to evaluate the diagnostic performance of FAM19A4, SOX1, and PAX1 methylation testing as a triage method for women aged 30 and older with positive non-16/18 high-risk HPV. Their findings indicate that this methylation testing not only correlates with the severity of cervical intraepithelial neoplasia (CIN) but also offers higher specificity and comparable sensitivity compared to traditional cytology, potentially reducing unnecessary colposcopy referrals and improving management strategies for these patients.
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