Could chemotherapy response score act as a surrogate marker of response to PARP inhibitor maintenance treatment in patients with advanced ovarian cancer?
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The authors aimed to determine if the Chemotherapy Response Score (CRS) could serve as a surrogate marker for predicting the benefit of PARP inhibitor maintenance treatment in patients with advanced ovarian cancer. Their findings indicate that patients with a higher CRS (2-3) experienced improved progression-free survival (PFS) with PARP inhibitor maintenance, while those with a lower CRS (1) did not show any survival benefit. This suggests that CRS may be a useful tool for guiding treatment decisions, especially in cases where genetic testing is not readily available.
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