Occult invasive and preneoplastic lesions at risk-reducing salpingo-oophorectomy in BRCA1/2 carriers: A multicenter retrospective cohort study
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The study aimed to evaluate the prevalence and types of occult invasive or preneoplastic lesions found in BRCA1/2 carriers undergoing risk-reducing salpingo-oophorectomy (RRSO). The findings revealed that approximately 10% of the women had occult invasive or microinvasive malignancies, with BRCA1 c.5266dupC being the most common recurrent variant among the cohort.
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