June 16, 2026 · American heart journal · DOI: 10.1016/j.ahj.2026.107513

The Effect of Zalunfiban on High Sensitivity Cardiac Troponin and the Association with Clinical Outcomes in Patients with STEMI

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This study investigates the effects of zalunfiban, a glycoprotein IIb/IIIa receptor blocker, on high sensitivity cardiac troponin (hs-cTnT) levels and clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI). The authors found that higher hs-cTnT concentrations at presentation were linked to worse reperfusion metrics and increased short-term mortality and heart failure risk, while zalunfiban treatment was associated with reduced hs-cTnT levels and smaller myocardial infarction size. Overall, the findings suggest that zalunfiban may improve outcomes in STEMI patients by mitigating myocardial injury.

James L Januzzi, C Michael Gibson, Gerald Chi, Barry S Coller, Christopher B Granger, Gilles Montalescot, Sem A O F Rikken, Ashley Verburg, Jurrien M Ten Berg, Arnoud W J van 't Hof, CELEBRATE Investigators

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