June 22, 2026 · American heart journal · DOI: 10.1016/j.ahj.2026.107516

Considerations for Using Atrial Fibrillation Burden as a Surrogate Endpoint A Report from the Cardiovascular Sciences Research Consortium

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The authors aim to establish atrial fibrillation (AF) burden as a valid surrogate endpoint for clinical trials, addressing the inadequacies of traditional measures of treatment success and failure in AF care. They propose a roadmap for validating AF burden through a collaborative approach, emphasizing its potential as a patient-centric measure that leverages modern monitoring technologies to better predict AF-related risks and improve trial efficiency.

Krishna Pundi, Charu Gandotra, William Sanders, Fortunato Senatore, Jason G Andrade, C Michael Gibson, Paulus Kirchhof, Steven A Lubitz, Jonathan Piccini, Andrea Russo, Kenneth Stein, Mintu P Turakhia, Jonathan Seltzer

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