Atezolizumab in combination with neoadjuvant chemotherapy and interval cytoreductive surgery for patients with newly diagnosed advanced-stage epithelial ovarian cancer: the AdORN study
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The AdORN study aimed to evaluate the safety and efficacy of atezolizumab, an immune checkpoint inhibitor, in combination with neoadjuvant chemotherapy for patients with newly diagnosed advanced-stage epithelial ovarian cancer. The results indicated that the treatment was feasible, did not delay interval cytoreductive surgery, and showed promising response rates, with notable changes in immune markers associated with treatment response. However, the study faced early termination due to negative results from a related trial, limiting patient enrollment and further analysis.
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