June 12, 2026 · The Journal of neuropsychiatry and clinical neurosciences · DOI: 10.1176/appi.neuropsych.20250144

The Neuropsychiatric Phenotype of Klüver-Bucy Syndrome: A Systematic Review of Reported Cases

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The authors conducted a systematic review to clarify the neuropsychiatric phenotype of Klüver-Bucy syndrome (KBS) by analyzing case reports and series to identify common symptoms and their variability. They found that hypersexuality, hyperorality, and hyperphagia were the most prevalent features, while cognitive changes and neuroimaging results indicated significant bilateral temporal lobe involvement. The review underscores the need for standardized diagnostic criteria and further research to enhance understanding and treatment of KBS.

Jose Fernando Muñoz, Jesús Ramírez-Bermúdez, Jordi Peña-Casanova, Diana Restrepo, Clara Gómez-Henk, José Ricardo Muñoz, Miguel Restrepo-Martínez

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