April 7, 2026 · The Journal of neuropsychiatry and clinical neurosciences · DOI: 10.1176/appi.neuropsych.20250222

Rehabilitation Therapies for Functional Neurological Disorder: A Systematic Review and Meta-Analysis of Clinical Trials

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The authors aimed to evaluate the efficacy of rehabilitation therapies for treating functional neurological disorder (FND) through a systematic review and meta-analysis of clinical trials. Their findings suggest that over 70% of participants experienced clinical improvement following rehabilitation, although the effect sizes varied significantly across studies. The authors conclude that while rehabilitation shows promise for FND symptoms, further high-quality randomized controlled trials are necessary to better understand its overall efficacy and the specific aspects of improvement it facilitates.

Eva S Keatley, Molly Cairncross, Shreya Raman, Ivan R Molton, Esther Choi, Kiarah O'Kane, Alison S Buchholz, Kathrin LaFaver, Rachel V Aaron

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