August 10, 2026 · Critical care medicine · DOI: 10.1097/CCM.0000000000007283

A 1-Hour Resuscitation Bundle for Prehospital Management of Septic Shock

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The authors aimed to evaluate the impact of a 1-hour resuscitation bundle, implemented by a mobile ICU team in a prehospital setting, on 28-day mortality in adults with septic shock. The study found no significant reduction in mortality rates between the group receiving the resuscitation bundle and the usual care group. The authors suggest that imbalances in patient enrollment and minimal differences in care may have influenced these results.

Romain Jouffroy, Djillali Annane, Caroline Elie, Jean Paul Mira, Léa Jilet, Papa Gueye, Benoît Vivien, and the Service d’Aide Médicale Urgente (SAMU) Save Sepsis study group

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