June 9, 2026 · American heart journal · DOI: 10.1016/j.ahj.2026.107510

Clinical Profiles to Guide Decongestion in Acute Heart Failure

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The authors aim to define actionable decongestion targets in acute heart failure by integrating diuretic resistance (DR) with residual congestion (RC) assessed at 72 hours post-treatment. Through a pooled analysis of two studies involving 636 patients, they identified four clinical profiles based on RC and DR that correlate with a 90-day risk of adverse outcomes, suggesting that this integrated approach may enhance risk stratification and guide therapeutic decisions.

Francisco B Alexandrino, Sílvio Nunes Augusto, Duarte Alexandrino, W H Wilson Tang

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