Dysregulated transcription in core- and pol-specific CD8 T cells can be targeted by HDAC inhibition to improve T-cell function in chronic hepatitis B

The authors investigate the dysregulated transcription in core- and polymerase-specific CD8 T cells in chronic hepatitis B (CHB) patients to understand the mechanisms behind T cell dysfunction and identify potential therapeutic targets. They find a distinct "resolution signature" of genes associated with T cell function that is altered in CHB but can be improved through histone deacetylase (HDAC) inhibition. This suggests that targeting transcriptional dysregulation may enhance T cell responses and offers a promising approach for immunotherapy in CHB.