The Hepato-Exposome Axis: How Endocrine Disruptors Hijack Liver Receptors to Drive MASLD

This review investigates how endocrine-disrupting chemicals (EDCs) contribute to the rising incidence of metabolically dysfunction-associated steatotic liver disease (MASLD) beyond traditional factors like obesity and diet. The authors propose the "hepato-exposome axis" framework to elucidate the interactions between specific EDCs and hepatic nuclear receptors, highlighting their roles in lipid metabolism, glucose homeostasis, and inflammation. They emphasize the need for further research on EDC mixtures and their effects on vulnerable populations to better understand and address the global MASLD burden.