Interleukin-19 ameliorates drug-induced liver injury by limiting proinflammatory macrophage infiltration via SUMOylation of C/EBPβ
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This study investigates the role of interleukin-19 (IL-19) in acetaminophen-induced liver injury (AILI) and its underlying inflammatory mechanisms. The authors find that IL-19 limits proinflammatory macrophage infiltration by promoting the SUMOylation of C/EBPβ, thereby reducing the expression of proinflammatory genes and mitigating AILI. These findings suggest that IL-19 could be a potential therapeutic target for treating AILI.
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