CD177+neutrophils promote endothelial senescence through extracellular traps in Behçet's Disease
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The authors investigate the role of CD177+ polymorphonuclear neutrophils (PMNs) in promoting endothelial cell senescence in Behçet's disease (BD), a chronic vasculitis. They find that CD177+ PMNs are expanded in BD patients and produce neutrophil extracellular traps (NETs) enriched with Histone 3.1, which induce senescence and a senescence-associated secretory phenotype in vascular endothelial cells through TLR4 signaling. This study highlights the contribution of CD177+ PMNs and their NETs to endothelial dysfunction and vasculitis in BD.
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