May 11, 2026 · JAMA internal medicine · DOI: 10.1001/jamainternmed.2026.1343

Testosterone Treatment in Prostate Cancer Survivors With Hypogonadism: A Randomized Clinical Trial

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This randomized clinical trial aimed to evaluate the short-term safety and efficacy of testosterone replacement therapy (TRT) in prostate cancer survivors with symptomatic hypogonadism. The study found that TRT significantly improved sexual activity, sexual desire, well-being, body composition, and physical function without causing biochemical recurrence of cancer. These results suggest that TRT may be beneficial for men with low-grade prostate cancer post-radical prostatectomy, although further long-term studies are needed to assess safety and recurrence risks.

Shalender Bhasin, Arthur L Burnett, Thiago Gagliano-Jucá, Thomas W Storer, Kieran F Reid, Yili Valentine Shang, Fabiola Privat, Mohan S Chandra, Mary Weiss, Yusnie Memish-Beleva, Helen Lam, Adam S Kibel, Karol M Pencina

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