T cell plasticity in systemic lupus erythematosus revealed by large-scale T cell receptor repertoire and transcriptome studies
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The authors aimed to characterize the plasticity of CD4<sup>+</sup> T cells in systemic lupus erythematosus (SLE) by analyzing T cell receptor (TCR) repertoire and transcriptomic data from a large cohort of SLE patients. They discovered a significant association between effector regulatory T cells and Th1 cells, revealing a Treg-associated Th1 state that correlates with disease activity in SLE. This study highlights the complex interplay between T cell subtypes in the context of autoimmune disease.
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