Kidney Hematopoietic Stem and Progenitor Cells Contribute to Myeloid Development and Pathology in Lupus Nephritis
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The authors investigate the role of extramedullary hematopoiesis (EMH) and kidney-resident hematopoietic stem and progenitor cells (HSPCs) in the pathogenesis of lupus nephritis (LN). They find that kidney-derived progenitor cells are enriched in LN models and correlate with disease severity, contributing to local myeloid cell expansion and kidney damage. The study suggests that targeting these kidney progenitors may provide new therapeutic strategies for managing inflammation in LN.
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