Therapeutic targeting protein kinase CK2 ameliorates lupus nephritis by modulating neutrophil infiltration and neutrophil extracellular trap formation
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The authors investigate the therapeutic potential of the protein kinase CK2 inhibitor CX-4945 in treating systemic lupus erythematosus (SLE) by examining its effects on neutrophil dysregulation and neutrophil extracellular trap (NET) formation. Their findings demonstrate that CX-4945 significantly improves renal function and reduces inflammation in murine models of lupus, suggesting that CK2α is a promising therapeutic target for SLE and related autoimmune conditions.
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