B-cell Maturation Antigen Targeted Chimeric Antigen Receptor T-cell Therapy for Refractory Systemic Lupus Erythematosus and Systemic Sclerosis
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The authors aimed to evaluate the safety and preliminary efficacy of HBI0101, a B-cell maturation antigen-targeted chimeric antigen receptor T-cell therapy, in patients with severe refractory systemic lupus erythematosus and systemic sclerosis. In a phase 1 trial involving six patients, the therapy demonstrated an acceptable safety profile, with manageable side effects, and showed early clinical activity, including significant improvements in disease symptoms. These findings support the need for further prospective studies to assess HBI0101's therapeutic potential.
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