Cytokine Profiling of Systemic Sclerosis-related Pulmonary Hypertension
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The authors aimed to develop a specific cytokine profile for systemic sclerosis-related pulmonary hypertension (SSc-PH) by analyzing circulating plasma cytokines in patients with systemic sclerosis. Utilizing multiplex immunoassays and a random forest modeling approach, they identified a 48-cytokine model with good predictive capability, ultimately refining it to a six-cytokine model that demonstrated high specificity. The study highlights the need for further external validation of this cytokine profile in prospective cohorts.
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