Gut Oxalate Transport and Gut Microbiome as Potential Therapeutic Targets for Hyperoxaluria and Hyperoxalemia: Implications for Related Human Disease

The authors investigate the potential of targeting gut oxalate transport and the gut microbiome as therapeutic strategies for managing hyperoxaluria and hyperoxalemia, conditions linked to kidney stones and chronic kidney disease. They highlight the role of the gut in oxalate homeostasis and the importance of oxalate-degrading bacteria in reducing oxalate absorption, while noting that most current evidence is based on animal studies, leaving a gap in understanding its relevance to human health.