Procr+ endothelial progenitor cells govern hematopoiesis through fine-tuning mesenchymal stem cell niche signals
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The authors investigate how Procr+ endothelial progenitor cells (EPCs) influence hematopoiesis through their interaction with mesenchymal stem cells (MSCs) in the bone marrow niche. They identify a signaling axis involving Procr, HSPA8, Foxc2, and Dll4 that is crucial for maintaining HSC self-renewal and myeloid output by regulating MSC differentiation. Their findings suggest that Procr+ EPCs play a vital role in sustaining vascular integrity and HSC maintenance, highlighting potential therapeutic strategies for niche regeneration.
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