The Evolution of Haematopoietic Models Through a Clonal Lens
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This review explores how haematopoiesis is regulated and how haematopoietic stem cells (HSCs) commit to specific lineages, emphasizing the need to understand these processes for improving cell therapy applications. The authors analyze various conceptual frameworks of haematopoiesis, supported by clonal lineage-tracing studies, and highlight the significance of clonal multi-omics approaches in identifying molecular predictors of lineage fate. They also address ongoing challenges in studying haematopoiesis in vivo and the need to uncover the molecular programs that dictate fate trajectories, particularly in the context of disease.
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