Engineering single-chain variable fragments to identify pathogenic antibodies in heparin-induced thrombocytopenia
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The authors aimed to develop epitope-specific inhibitors to identify pathogenic antibodies in heparin-induced thrombocytopenia (HIT), which are known to activate platelets and cause complications. They engineered single-chain variable fragments (scFvs) derived from a monoclonal antibody to selectively inhibit the binding of these pathogenic antibodies while leaving non-pathogenic antibodies unaffected. Their findings suggest that these scFvs can enhance the diagnostic accuracy of tests for HIT by targeting a shared pathogenic epitope on platelet factor 4 (PF4).
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