Bone Marrow Stem Cell Connexins: Misconceptions and New Insights
Listen to this summary
This review explores the role of connexins, particularly Connexin-43 (Cx43), in hematopoietic stem and progenitor cell (HSPC) regulation during stress hematopoiesis and bone marrow microenvironment remodeling. The authors aim to clarify misconceptions about connexins by highlighting their multifaceted functions beyond gap junctions, including their impact on metabolic coupling and regenerative signaling, and propose targeted therapeutic strategies to enhance hematopoietic recovery and address hematologic malignancies.
This is one of 33,000+ journals available on OSLR. Try it free for 14 days.
Free 14-day trial. 33,000+ journals. Cancel anytime.
More from Blood
View all →May 8, 2026 · Blood
Ikaros degradation by mezigdomide reduces T-cell dysfunction and improves the efficacy of antimyeloma T-cell therapies
May 8, 2026 · Blood
Procr+ endothelial progenitor cells govern hematopoiesis through fine-tuning mesenchymal stem cell niche signals
May 7, 2026 · Blood
Engineering single-chain variable fragments to identify pathogenic antibodies in heparin-induced thrombocytopenia
May 7, 2026 · Blood
How I utilize somatic alterations in the diagnosis, risk stratification, and therapy of hypocellular bone marrow failure
May 7, 2026 · Blood
JMJD1C-mediated epigenetic control of autoimmunity and HIT antibody production
May 6, 2026 · Blood
The Evolution of Haematopoietic Models Through a Clonal Lens
More in Internal Medicine
View all →May 10, 2026 · JAMA
Digoxin in Patients With Symptomatic Rheumatic Heart Disease: A Randomized Clinical Trial
May 10, 2026 · European heart journal
Blinded withdrawal of randomized treatment with low-dose digoxin or placebo in patients with heart failure: the DECISION trial
May 10, 2026 · Lancet (London, England)
Endovascular thrombectomy for patients with large-core ischaemic stroke presenting up to 24 h after onset (ATLAS): a systematic review and individual patient data meta-analysis with central imaging adjudication
May 10, 2026 · European heart journal
Renin-angiotensin-aldosterone system inhibition and haemocompatibility-related adverse events in patients with durable left ventricular assist device: the MOMENTUM-3 trial
May 10, 2026 · JAMA
Efficacy and Safety of Digitalis Glycosides in Heart Failure: A Meta-Analysis
May 10, 2026 · Lancet (London, England)
Impact of introducing RTS,S/AS01<sub>E</sub> malaria vaccine on mortality in young children in Ghana, Kenya, and Malawi: an observational evaluation of a cluster-randomised implementation programme
"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."
Dr. Jennifer Thompson
Portland, OR
Stay current without falling behind
33,000+ journals. 3-minute audio summaries. Free for 14 days.
