May 1, 2026 · Blood · DOI: 10.1182/blood.2025032145

How I Treat Plasma Cell Leukemia

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The authors aim to address the treatment strategies for plasma cell leukemia (PCL), an aggressive form of plasma cell malignancy characterized by specific clinical features and high-risk genetic abnormalities. They review current therapeutic options, including novel targeted therapies, while emphasizing the need for dedicated clinical trials to fill knowledge gaps and improve outcomes for PCL patients, who are often excluded from multiple myeloma studies.

Samer Al Hadidi, Frits van Rhee, Larry D Anderson

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Dr. Jennifer Thompson

Dr. Jennifer Thompson

Portland, OR

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