April 29, 2026 · Gastroenterology · DOI: 10.1053/j.gastro.2026.03.027

Chronic Pancreatitis: Mechanisms of Inflammation, Pathways of Progression and Emerging Therapeutic Strategies

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The authors investigate the mechanisms of inflammation and pathways of progression in chronic pancreatitis, a disease characterized by recurrent abdominal pain and pancreatic dysfunction. They highlight the challenges in early diagnosis due to a lack of validated biomarkers and the need for improved therapeutic strategies that can modify disease progression. The review emphasizes the importance of developing a patient-tailored approach to therapy that targets inflammation and preserves pancreatic function.

Soumya Jagannath Mahapatra, Sudipta Dhar Chowdhury, Venkata Sandeep Akshintala, Pramod Kumar Garg

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