April 24, 2026 · Gastroenterology · DOI: 10.1053/j.gastro.2026.01.040

Fundamentals of Neurogastroenterology: Basic Science

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This review aims to synthesize recent advancements in neurogastroenterology since the Rome IV criteria, particularly focusing on the complex mechanisms underlying disorders of gut-brain interaction (DGBI). The authors explore how various biological systems interact and contribute to DGBI, while also discussing the potential for new therapeutic strategies informed by these scientific insights. Key themes include brain-gut interactions, neuroplasticity, and the role of the microbiome, all of which are essential for understanding and treating these multifactorial disorders.

Beverley Greenwood-Van Meerveld, Gary M Mawe, Arthur Beyder, Stuart M Brierley, Gerard Clarke, Brian D Gulbransen, Kara G Margolis

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