Bioengineering a probiotic to bloom during colonic inflammation promotes reliable efficacy in translational models of colitis
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The authors aimed to determine whether bioengineering E. coli Nissle 1917 (EcN) with the ttr operon (EcN::ttr) could enhance its effectiveness in treating colitis by allowing it to thrive during intestinal inflammation. Their findings demonstrated that EcN::ttr significantly improved colitis outcomes compared to both EcN and standard treatments, promoting immunoregulatory responses and beneficial changes in the gut microbiome. This study suggests that EcN::ttr could serve as a novel microbiome therapeutic for inflammatory bowel diseases (IBD).
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