April 28, 2026 · Radiology · DOI: 10.1148/radiol.252637

Association between CT-evaluated Poststenotic Dilatation in Human Renal Artery Stenosis and Kidney Release of MCP-1

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The authors investigate the mechanisms underlying poststenotic dilatation (PSD) in patients with renal artery stenosis (RAS) and its association with kidney damage, specifically focusing on the release of monocyte chemoattractant protein-1 (MCP-1). Their findings reveal that higher levels of MCP-1 in the stenotic kidney correlate positively with the dilatation-diameter ratio and are associated with lower kidney function, suggesting a potential link between PSD and renal injury. Additionally, while percutaneous transluminal renal angioplasty did not improve kidney function, it did lead to regression of PSD, which was inversely related to MCP-1 levels.

Mina Al Saeedi, Dilbar A Abdurakhimova, Tarek Arabi, Jakob Nyvad, Mouaz Oudih, Li Xing, Bo Lu, Lei Zhang, Xiangyang Zhu, Sanjay Misra, Amir Lerman, Lilach O Lerman

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