Consortium on Bridging Radiation Segmentectomy (COBRAS): A Multicenter Study of Complete Pathologic Necrosis in Hepatocellular Carcinoma
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The study aimed to evaluate the outcomes of glass microsphere radiation segmentectomy in achieving complete pathologic necrosis (CPN) in patients with treatment-naive hepatocellular carcinoma (HCC) prior to liver transplant. The findings revealed a CPN rate of 68%, with specific treatment parameters—such as microsphere activity, dose, and angiosome-to-tumor volume ratio—identified as independent predictors of achieving CPN. This research highlights the importance of optimizing these parameters to improve patient outcomes in liver transplantation for HCC.
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