April 27, 2026 · Arthritis & rheumatology (Hoboken, N.J.) · DOI: 10.1002/art.70205

Differences in SARS-CoV-2 antigen persistence in individuals with systemic autoimmune rheumatic diseases compared to the general population: A RECOVER-Adult Cohort Study

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This study investigates whether individuals with systemic autoimmune rheumatic diseases (SARDs) exhibit longer persistence of SARS-CoV-2 antigens compared to the general population following COVID-19 infection. The findings reveal that individuals with SARDs have significantly higher rates of antigen positivity at both 3 and 6 months post-infection, suggesting a prolonged viral presence that is not attributable to demographic factors, vaccination status, or treatment.

Naomi J Patel, Zoe Swank, Jiaqi Wang, Xiaosong Wang, Lauren A O'Keeffe, Madison Negron, Liya S Getachew, Louise L Hansen, Grace Qian, Alene A Saavedra, Kevin T Mueller, Natalie A Davis, Kathleen M M Vanni, Sandria Savage, Julie S Lam, Zachary S Wallace, David R Walt, Jeffrey A Sparks, RECOVER‐Adult

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